The research team is hosted in an outstanding institute, the ICM, a joint-venture between French public institutions (INSERM, CNRS; Université Pierre et Marie Curie, Assistance Publique – Hôpitaux de Paris) and the private ICM Foundation. The ICM is a new research building located at the heart of la Pitié Salpetrière Hospital, which is one of the largest hospitals in Europe. The ICM occupies 22,000 m2 of laboratory space, and benefits from four research MRIs, an outstanding biological resource center, 600 researchers, engineers and technicians working on-site. Research at ICM is organized in 25 research teams studying the nervous systems at micro-, meso- and macro-scales, focusing on basic, translational and clinical research (http://www.icm-institute.org for details). Importantly, the ICM is located in Paris, which hosts an outstanding community of neuroscientists, within the >20 academic institutions located in the Paris metropolitan area. For Ph.D. training, the ICM is affiliated to the graduate program Ecole Doctorale Cerveau Cognition Comportement (ED3C), part of Sorbonne Université.
Role in the project
In addition to the above-mentioned brain imaging infrastructures, and more relevant for this research program, the Institute harbors state-of-the-art technical facilities: Cell Culture; Sequencing and genotyping; Microscopy (electron microscopy, advanced confocal and multi-photon microscopy, image analysis); Vectorology; Multi-species animal research facility, equipped with surgery and experimental rooms for microsurgery and behavior. In particular, the host lab is fully equipped with all the necessary infrastructure and equipment to carry out the proposed work: 1) An electrophysiological rig for in vivo (awake) recordings (patch and LFP); 2) A 2-photon rig for in vivo (awake) experiments equipped with resonant scanners and dual scan-head for photo-stimulations; 3) Four patch-clamp rigs for multiple (up to four simultaneously) patch clamp recordings in acute slices; 4) A Neurolucida setup for morphometric quantifications and reconstructions; 5) A wet lab for immunohistochemistry and molecular biology preparations.